Endocrine Abstracts

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a systemic, metabolic condition associated with increased morbidity and mortality. Defined by an increase in hepatic lipid content (HCL), NAFLD develops in consequence of lipid oversupply and/or a diminished disposal of hepatic lipids. The latter may include an impaired export of triglycerides (TG) via the secretion of very-low density lipoprotein1 (VLDL1) particles, an important mechanism of the liver to protect itsel...

Overview: Non-alcoholic fatty liver disease (NAFLD) is defined as a chronic increase in intrahepatic lipids (IHL). A surplus of IHL can be compensated through increased lipid export via very-low density lipoprotein (VLDL) particles. Growth hormone (GH) is known to reduce visceral and ectopic fat. However, the main pathways responsible for the in-vivo decrease of IHL under the influence of GH are yet to be determined.Methods: We assessed hepatic lipid met...